Naturopath Factsheet

1. Șerban M, Toader C, Covache-Busuioc RA. The Endocannabinoid System in Human Disease: Molecular Signaling, Receptor Pharmacology, and Therapeutic Innovation. Int J Mol Sci. 2025 Nov 18;26(22):11132. doi: 10.3390/ijms262211132. PMID: 41303613; PMCID: PMC12653933.

2. Henshaw FR, Dewsbury LS, Lim CK, Steiner GZ. The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of In Vivo Studies. Cannabis Cannabinoid Res. 2021 Jun;6(3):177-195. doi: 10.1089/can.2020.0105. Epub 2021 Apr 28. PMID: 33998900; PMCID: PMC8266561

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3. Sharkey KA, Wiley JW. The Role of the Endocannabinoid System in the Brain-Gut Axis. Gastroenterology. 2016 Aug;151(2):252-66. doi: 10.1053/j.gastro.2016.04.015. Epub 2016 Apr 29. PMID: 27133395; PMCID: PMC4961581.

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4. Vila Silván C, Vaney C, Dykukha I. Systematic reviews of randomized controlled trials of cannabinoid products in chronic pain conditions and for symptoms associated with multiple sclerosis: what do they tell us? Expert Rev Clin Pharmacol. 2022 Apr;15(4):415-431. doi: 10.1080/17512433.2022.2088501. Epub 2022 Aug 3. PMID: 35679523.

5. Perisetti A, Rimu AH, Khan SA, Bansal P, Goyal H. Role of cannabis in inflammatory bowel diseases. Ann Gastroenterol. 2020 Mar-Apr;33(2):134-144. doi: 10.20524/aog.2020.0452. Epub 2020 Feb 12. PMID: 32127734; PMCID: PMC7049239.

6. Sherpa ML, Shrestha N, Ojinna BT, Ravi N, Shantha Kumar V, Choday S, Parisapogu A, Tran HH, Kc A, Elshaikh AO. Efficacy and Safety of Medical Marijuana in Migraine Headache: A Systematic Review. Cureus. 2022 Dec 17;14(12):e32622. doi: 10.7759/cureus.32622. PMID: 36660507; PMCID: PMC9845509.

7. Winiger EA, Hitchcock LN, Bryan AD, Cinnamon Bidwell L. Cannabis use and sleep: Expectations, outcomes, and the role of age. Addict Behav. 2021 Jan;112:106642. doi: 10.1016/j.addbeh.2020.106642. Epub 2020 Sep 6. PMID: 32949837; PMCID: PMC7572650.

8. Rehman Y, Saini A, Huang S, Sood E, Gill R, Yanikomeroglu S. Cannabis in the management of PTSD: a systematic review. AIMS Neurosci. 2021 May 13;8(3):414-434. doi: 10.3934/Neuroscience.2021022. PMID: 34183989; PMCID: PMC8222769.

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9. Blessing EM, Steenkamp MM, Manzanares J, Marmar CR. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015 Oct;12(4):825-36. doi: 10.1007/s13311-015-0387-1. PMID: 26341731; PMCID: PMC4604171.

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10.Singh K, Bhushan B, Chanchal DK, Sharma SK, Rani K, Yadav MK, Porwal P, Kumar S, Sharma A, Virmani T, Kumar G, Noman AA. Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review. Behav Neurol. 2023 Oct 12;2023:8825358. doi: 10.1155/2023/8825358. PMID: 37868743; PMCID: PMC10586905.

11.Walsh KB, McKinney AE, Holmes AE. Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses. Front Pharmacol. 2021 Nov 29;12:777804. doi: 10.3389/fphar.2021.777804. PMID: 34916950; PMCID: PMC8669157.

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12.Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A. Beta-caryophyllene is a dietary cannabinoid. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(26):9099–9104.

13. Klauke AL, Racz I, Pradier B, Markert A, Zimmer AM, Gertsch J, Zimmer A. The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models. European Neuropsychopharmacology. 2014;24(4):608–620.

14. van Daal MT, Folkerts G, Garssen J, Braber S. Pharmacological modulation of immune responses by nutritional components. Pharmacological Reviews. 2021;73(4):1369–1403. doi:10.1124/pharmrev.120.000063

‍

15. Brum LF, Moreira FA, Frussa-Filho R, Campos MM. Anxiolytic-like effect of linalool inhalation in mice. Pharmacology Biochemistry and Behavior. 2001;69(3–4):555–561. https://doi.org/10.1016/S0091-3057(01)00544-0

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16. Aprotosoaie AC, Hăncianu M, Costache II, Miron A. Linalool: A review on a key odorant molecule with valuable biological properties. Flavour and Fragrance Journal. 2014;29(4):193–219. https://doi.org/10.1002/ffj.3215

‍

17. Souza RS, da Silva RF. Therapeutic potential of linalool: a review. Biomedicine & Pharmacotherapy. 2018;106:1333–1340. https://doi.org/10.1016/j.biopha.2018.07.093

‍

18. Liktor-Busa E, Keresztes A, LaVigne J, Streicher JM, Largent-Milnes TM. Analgesic potential of terpenes derived from Cannabis sativa. Pharmacological Reviews. 2021;73(4):1269–1297. https://doi.org/10.1124/pharmrev.120.000100

‍

19. Martel F, Maurice T, Wolfender JL. Effects of terpenes on the central nervous system: focus on cognitive and emotional effects. Natural Product Reports. 2016;33(6):656–676. https://doi.org/10.1039/C6NP00010A

‍

20. Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. Journal of Nutrition. 1999;129(3):775S–778S. https://doi.org/10.1093/jn/129.3.775S

‍

21. Hasanein P, Shahidi S. Effects of myrcene on diabetic neuropathic pain in rats. Basic & Clinical Pharmacology & Toxicology. 2018;122(6):641–647. https://doi.org/10.1111/bcpt.12932

‍

22. Viana GSB, de Oliveira AC, do Vale TG, et al. Central nervous system effects of myrcene. Journal of Pharmacy and Pharmacology. 2005;57(5):591–596. https://doi.org/10.1211/0022357055968

‍

23. Chaves CM, et al. Pharmacological effects of α-humulene. Pharmacology Biochemistry and Behavior. 2008;88(3):298–307.

24. LaVigne J, Hecksel R, Freedlander K, et al. Cannabimimetic activity of terpenes in the cannabinoid tetrad in mice. Scientific Reports. 2021;11:9481.

‍

25. Chen SH, Chen HH, Chen JY. Antioxidant effects of α-pinene on oxidative stress in rats. Food and Chemical Toxicology. 2015;75:114–120. https://doi.org/10.1016/j.fct.2014.10.027

‍

26. Kim YS, Kim KA, Kim MJ. Anti-inflammatory effects of α-pinene in mouse peritoneal macrophages. Food and Chemical Toxicology. 2015;78:161–167. https://doi.org/10.1016/j.fct.2015.02.017

‍

27. Gulcin I. Antioxidant activity of food constituents: An overview. Archives of Toxicology. 2019;94(8):2293–2335. https://doi.org/10.1007/s00204-020-02775-0

‍

28. van Daal MT, Folkerts G, Garssen J, Braber S. Pharmacological modulation of immune responses by nutritional components. Pharmacological Reviews. 2021;73(4):1369–1403. https://doi.org/10.1124/pharmrev.120.000063

29. Satyal P, Shrestha S, Setzer WN. Composition and bioactivities of an (E)-β-farnesene chemotype of Matricaria chamomilla essential oil from Nepal. Natural Product Communications. 2015;10(8):1453–1457.

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30. Qasem A, Al-Hajj N, Al-Rimawi F, et al. Determination of chemical compounds and investigation of biological properties of Matricaria chamomilla essential oils, honey, and their mixture. Molecules. 2022;27(18):5850.

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31. Cho JY, et al. Inhibitory effects of (−)-α-bisabolol on LPS-induced inflammatory response via AP-1 and NF-κB in RAW 264.7 macrophages. Food and Chemical Toxicology. 2011;49(10):2580–2585. doi:10.1016/j.fct.2011.06.067

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32. Oliveira FA, Andrade LN, Sousa DP. Anti-nociceptive and anti-inflammatory activities of (−)-α-bisabolol in rodents. Naunyn-Schmiedeberg’s Archives of Pharmacology. 2011;384(6):525–533. doi:10.1007/s00210-011-0679-x

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33. Bastaki SMA, Amir N, Ojha S, Adeghate E. α-Bisabolol attenuates oxidative stress and inflammation in acetic-acid colitis in rats. International Journal of Molecular Sciences. 2025;26(17):8168. doi:10.3390/ijms26178168