Epilepsy is a complex neurological condition that affects millions of people worldwide. This disorder disrupts the normal electrical activity in the brain, causing recurrent seizures of differing intensities and frequencies. The impact of epilepsy goes beyond just physical symptoms and can affect cognitive abilities and emotional well-being too.
The seizures and their aftermath can be both physically debilitating and emotionally distressing, which is why it’s so important for doctors to tailor treatment plans to meet the physical and emotional needs of epilepsy patients.
While conventional antiepileptic medications have been a major advancement in epilepsy management, they are not always entirely effective and can be associated with undesirable side effects. This has prompted both patients and the medical community to explore alternative approaches, such as medicinal cannabis, which can be used as a complementary therapy or a stand-alone treatment.
Medicinal cannabis, commonly referred to as medical marijuana, has gained recognition for its potential to alleviate epilepsy symptoms for some patients naturally. The compounds found in medical cannabis, particularly cannabidiol (CBD), have shown promise in reducing the frequency and severity of seizures in certain individuals with epilepsy. These positive findings have encouraged further research into how cannabinoids interact with the nervous system to help reduce the intensity or frequency of seizures.
Read on to find out how medical cannabis may help some patients manage epilepsy.
What is epilepsy?
Epilepsy is a spectrum of neurological disorders characterised by abnormal brain activity, resulting in recurrent seizures. These seizures can vary widely in their manifestations and severity, and can impact people differently. Because of epilepsy's diverse nature can diagnosis and treatment can be complicated
Seizures associated with epilepsy can range from subtle moments of altered consciousness or brief staring spells to more intense convulsions. The type of seizure someone experiences depends on the part of the brain affected and the pattern of abnormal activity it generates.
There are different types of epilepsy, and each has its distinct set of challenges. Some people may experience focal onset seizures, which originate in a specific area of the brain, while others may have generalised onset seizures that involve widespread brain networks. Additionally, there are epilepsy syndromes that tend to manifest in specific age groups and are characterised by specific seizure types and patterns.
Managing epilepsy effectively requires accurate diagnosis and personalised treatment plans. Antiepileptic medications are commonly prescribed to control seizure activity, but their effectiveness can vary depending on the type of epilepsy and individual response. In some cases, surgery may be considered to remove or isolate the epileptic focus (the part of the brain where the seizure originates).
If you or a loved one are living with epilepsy and want to explore natural treatment support, medical professionals can help you make an informed decision about your treatment options.
Challenges of Traditional Epilepsy Treatments
Managing epilepsy involves a multifaceted approach that often relies on antiepileptic medications (also known as “anti-seizure medications”). These medications have greatly improved the lives of many people by helping them control seizures and achieve a better quality of life. However, while traditional epilepsy medications are effective for many, they are not without potential challenges.
One of the notable benefits of modern epilepsy medications is their ability to significantly reduce the frequency and severity of seizures for many people with epilepsy. These medical advancements have revolutionised epilepsy management, allowing people to regain a sense of control and stability in their lives.
However, there has been growing interest in the potential therapeutic benefits of medicinal cannabis as an adjunct therapy for epilepsy. While not always a suitable replacement for modern epilepsy medications, some individuals find that incorporating medicinal cannabis into their treatment plan may provide additional relief or help them avoid common side effects like dizziness, fatigue, weight gain, and mood changes.
Cannabidiol (CBD), a non-psychoactive compound found in medical cannabis, has shown promise in reducing certain types of seizures, particularly in cases where traditional medications may not be fully effective. However, it's important to note that medicinal cannabis is not suitable for everyone, and its use should be discussed with healthcare providers, like an authorised prescriber or doctor. Remember: When making decisions about epilepsy treatment options (whether that involves traditional medications, adjunct therapies like medicinal cannabis, or a combination of both) it’s important to make these decisions with the help of a trusted doctor.
How Medical Cannabis May Impact Patients with Epilepsy
The potential therapeutic role of medical cannabis in managing epilepsy has garnered increasing interest, shedding light on its possible therapeutic benefits for some individuals living with seizure disorders. Exploring the interaction between medical cannabis and the neurological system can provide insights into its potential efficacy in mitigating the challenges posed by epilepsy.
- Neurological Regulation: Medical cannabis compounds, including CBD and THC, interact with the body's endocannabinoid system (ECS), a complex network of receptors and signalling molecules involved in maintaining neurological balance.
CBD, for instance, has shown promise in influencing GABA receptors, which play a critical role in inhibiting excessive neuronal activity. By modulating these receptors, CBD may help regulate abnormal brain activity associated with seizures in some patients.
- Seizure Threshold Modulation: Both CBD and THC have been studied for their effects on altering the seizure threshold, which is the point at which an individual is more susceptible to experiencing a seizure.
CBD's anticonvulsant properties show potential in raising the seizure threshold, thereby reducing the frequency and intensity of seizures. However, the influence of THC on seizures requires careful consideration due to its potential to lower the seizure threshold in some cases.
- Neuroprotective Effects: CBD's neuroprotective properties have gained attention for their potential in safeguarding brain cells from damage caused by seizures. Research suggests that CBD's antioxidant and anti-inflammatory actions may help mitigate the neurodegenerative effects associated with epilepsy, providing a multifaceted approach to managing the condition for some patients.
- Inflammation and Excitotoxicity: Inflammation and excitotoxicity, an excessive release of neurotransmitters that can lead to neuronal damage, are implicated in epilepsy. CBD's anti-inflammatory and antioxidant properties may counteract these processes in some patients, offering a protective effect against the neurological damage that can occur during seizures.
- Medication-Resistant Epilepsy: A particularly challenging form of epilepsy is medication-resistant epilepsy, where traditional antiepileptic drugs do not provide adequate seizure control. Medical cannabis, with its unique mechanisms of action, may offer a potential alternative for some individuals who have not responded well to conventional treatments. CBD-rich formulations, in particular, have shown promise in reducing seizure frequency in some cases.
- Dosage and Personalized Treatment: It's important to note that the effects of medical cannabis on epilepsy can vary widely based on factors such as dosage, cannabinoid ratios, and an individual's specific response. Working closely with medical professionals to establish appropriate dosing and monitoring is crucial to achieving optimal outcomes.
- Seizure Reduction: One of the most therapeutically beneficial aspects of medicinal cannabis for epilepsy is its potential to reduce seizure frequency and severity in some patients, particularly those with treatment-resistant forms of epilepsy, such as Dravet syndrome and Lennox-Gastaut syndrome.
- Improved Quality of Life: Patients who experience fewer seizures often report an improved quality of life. Reduced seizure frequency can lead to better cognitive function, improved mood, and enhanced social interactions.
- Reduced Medication Dependency: Some individuals with epilepsy may be able to reduce their reliance on traditional antiepileptic medications when using medicinal cannabis, which can be beneficial, especially if they experience adverse side effects from these medications.
- Alternative for Intractable (hard-to-treat) Epilepsy: For people who do not respond well to conventional epilepsy treatments, medicinal cannabis may offer a much-needed alternative, potentially providing hope where other options have failed.
While further research is needed to fully understand its mechanisms and effects, medical cannabis offers hope for some people wanting additional options for epilepsy care to address the challenges posed by this complex neurological condition.
Possible Risks of Medicinal Cannabis for Epilepsy
Before starting on a course of medicinal cannabis treatment for epilepsy, it is important to carefully evaluate any potential risks to make informed decisions about your medical treatment.
- Side Effects: While CBD is generally considered safe and well-tolerated, THC and other prominent compounds in cannabis can cause side effects such as dizziness, increased heart rate, and cognitive impairment. These side effects may be particularly concerning for vulnerable populations, such as children or the elderly.
- Drug Interactions: Medicinal cannabis can interact with other medications, potentially affecting their effectiveness or causing adverse reactions. It is crucial for patients to inform their healthcare providers about their cannabis use to manage potential drug interactions properly.
- Long-Term Safety: The long-term safety of medicinal cannabis for epilepsy requires further clinical trials. Concerns about potential adverse effects on brain development in children and adolescents and the risk of addiction need to be carefully considered.
- Individual Variation: Responses to medicinal cannabis can vary significantly among individuals. What works for one person may not work for another, making it challenging to predict outcomes and customise treatment effectively.
Ongoing research and increased understanding of medicinal cannabis treatments are critical for maximising the therapeutic benefits and minimising the risks associated with its use in epilepsy management.
The Wrap Up
Epilepsy is a complex disorder that disrupts the normal electrical activity in the brain and causes recurrent seizures. While traditional medications have played an important role in managing this condition, medicinal cannabis, particularly CBD-rich formulations, shows promise as an alternative or complementary therapy, especially for some medication-resistant epilepsy.
Medical Cannabis and Epilepsy FAQs
Is cannabinoid oil for epilepsy?
Yes, cannabinoid oil, also known as CBD oil, has been studied and used as a potential treatment for epilepsy, particularly in cases where other treatments have not been effective. The TGA has approved a CBD-based medication called Epidiolex for specific forms of severe epilepsy. This medication was also the first and only medicinal cannabis medication to be listed on Australia’s Pharmaceutical Benefits Scheme (PBS). However, it's important to consult with a healthcare professional before using CBD oil for epilepsy, as its effectiveness can vary from person to person, and other treatment options should also be considered.
How can I prevent seizures?
To prevent seizures, especially while considering the use of medicinal cannabis, it is essential to consult with a healthcare professional, such as a neurologist, epilepsy specialist, or an expert doctor, for personalised guidance. For many people, prescription medications are the primary means of seizure control, and adherence to the prescribed regimen is important. Lifestyle adjustments, like maintaining a regular sleep schedule, managing stress, and avoiding personal seizure triggers, can also be helpful. If appropriate, medicinal cannabis containing CBD or low levels of THC may be considered as part of the treatment plan, but it should be closely monitored by a qualified healthcare provider. Additionally, other options like Vagus Nerve Stimulation (VNS), Responsive Neurostimulation (RNS), or surgery may be explored in cases where seizures are not responsive to medications or other treatments.
- Ahuja AS. Cannabis-based treatments as an alternative remedy for epilepsy. Integr Med Res. 2019;8(3):200-201. doi:10.1016/j.imr.2019.07.003
- Atalay S, Jarocka-Karpowicz I, Skrzydlewska E. Antioxidative and Anti-Inflammatory Properties of Cannabidiol. Antioxidants (Basel). 2019;9(1):21. Published 2019 Dec 25. doi:10.3390/antiox9010021
- Australian Government Department of Health Therapeutic Goods Administration. Guidance for the use of medicinal cannabis in Australia - Patient information. [Internet]. Available from: https://www.tga.gov.au/resources/resource/guidance/guidance-use-medicinal-cannabis-australia-patient-information#:~:text=The%20known%20side%2Deffects%20from,%2C%20dry%20mouth%2C%20and%20diarrhoea. Accessed 5 September 2023.
- Devinsky OP, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, et al. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Neurol. 2016;15(3):270-278. doi:10.1016/S1474-4422(15)00379-8
- Epilepsy Foundation. Side Effects of Antiepileptic Medications. [Internet]. Available from: https://www.epilepsy.org.au/strong-foundations/how-epilepsy-can-affect-learning/side-effects-of-antiepileptic-medications/. Published [insert publication date] (if available). Accessed 5 September 2023.
- Fernández-Ruiz J, Sagredo O, Pazos MR, et al. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?. Br J Clin Pharmacol. 2013;75(2):323-333. doi:10.1111/j.1365-2125.2012.04341.x
- Goldenberg MM. Overview of drugs used for epilepsy and seizures: etiology, diagnosis, and treatment. P T. 2010;35(7):392-415.
- Gordon, E., Devinsky, O. (1999). Marihuana: Effects on Neuronal Excitability and Seizure Threshold. In: Nahas, G.G., Sutin, K.M., Harvey, D., Agurell, S., Pace, N., Cancro, R. (eds) Marihuana and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-710-9_61
- Peng J, Fan M, An C, Ni F, Huang W, Luo J. A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD). Published online January 26, 2022. doi:10.1111/bcpt.13710
- Perucca E. Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last?. J Epilepsy Res. 2017;7(2):61-76. Published 2017 Dec 31. doi:10.14581/jer.17012
The information on this website is provided for educational and informational purposes only and not intended for use as medical advice. Polln is not promoting the use of medicinal cannabis. Medicinal cannabis in Australia is scheduled medication and regulated by the Therapeutic Goods Administration (TGA). Details about medicinal cannabis as a scheduled drug can be found on their website. If you would like to explore medicinal cannabis for your chronic condition, please consult with a doctor.
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